Canadian Center for Alternatives to Animal Methods (CCAAM), University of Windsor. CCAAM and the Canadian Centre for the Validation of Alternative Methods (CaCVAM) aim to develop, validate, and promote non-animal, human biology-based platforms in biomedical research, education, and chemical safety testing.

Canadian Centre for the Validation of Alternative Methods (CaCVAM), University of Windsor. The overarching goal of CaCVAM is to work in partnership with Canadian regulators—primarily Health Canada—to expedite the development, validation, and regulatory acceptance of new approach methodologies (alternatives to animal testing) to modernize toxicity testing in Canada.

United States

Alternatives Research and Development Foundation (ARDF)

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins University

Center for Animal Alternatives Information, University of California, Davis

Evidence-based Toxicology Collaboration

In Vitro and Alternative Methods Specialty Section of the Society of Toxicology (IVAM)

Institute for In Vitro Sciences (IIVS)

Society for In Vitro Biology (SIVB)


3R Research Foundation (Switzerland)

3Rs-Centre Utrecht Life Sciences (The Netherlands)

Animal Replacement Centre of Excellence (ARC) (UK)

Bf3R – Federal Institute for Risk Assessment (Germany)

Center for Alternatives to Animal Testing – Europe (CAAT-Europe) (Germany)

Centre for Documentation and Evaluation of Alternatives to Animal Experiments (ZEBET) Federal Institute for Risk Assessment (BfR) (Germany)

CZECOPA (Czech Republic)

Danish 3R-Center (Denmark)

Dr Hadwen Trust (UK)

European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM)

European Consensus-Platform for Alternatives (ECOPA)

European Partnership for Alternative Approaches to Animal Testing (EPAA)

European Society for Alternatives to Animal Testing (EUSAAT)

European Society for Animal Cell Technology (ESACT)

European Society of Toxicology In Vitro (ESTIV)

EUROTOX: Federation of European Toxicologists & European Societies of Toxicology

Federal Food Safety and Veterinary Office FSVO – (Switzerland – participating as observer since 2016)

Finnish Centre for Alternative Methods (FICAM)

FINCOPA (Finland)


Fund for the Replacement of Animals in Medical Experiments (FRAME)

IZSLER – Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (Italy)

NC3Rs – The National Centre for the Replacement, Refinement and Reduction of Animals in Research (UK)

Norecopa – (Norway)

RIVM – National Institute for Public Health and the Environment (The Netherlands)

ROCAM – Romanian Center for Alternative Test Methods (Romania)

SWETOX – Swedish Toxicology Sciences Research Center (Sweden)